D E P A R T M E N T S:

DISCOVERY!:

Materials Science: Biological Aspects

Gottfried Schmalz
The author discusses the biological aspects of dental materials and their applications as integral parts of both dentistry and medicine.

J Dent Res 2002 81: 660-663. [Full Text] [PDF]  

RAPID COMMUNICATION:

Assessment of Enamelysin (MMP-20) Selectivity to Three Peptide Bonds on Amelogenin Sequence

L. Wang and J. Moradian-Oldak
Folding and assembly are the primary factors in controlling the pattern of amelogenin proteolysis during the secretory stage of enamel development.

J Dent Res 2002 81: 664-667. [Abstract] [Full Text] [Figures Only] [PDF]  

Tissue Engineering of Complex Tooth Structures on Biodegradable Polymer Scaffolds

C.S. Young, S. Terada, J.P. Vacanti, M. Honda, J.D. Bartlett, and P.C. Yelick
The authors demonstrate the first successful generation of tooth crowns from dissociated tooth tissues that contain both dentin and enamel, and suggest the presence of epithelial and mesenchymal dental stem cells in porcine third molar tissues.

J Dent Res 2002 81: 695-700. [Abstract] [Full Text] [Figures Only] [PDF]  

Chondrocyte Proliferation of the Cranial Base Cartilage upon in vivo Mechanical Stresses

X. Wang and J.J. Mao
Genetically coded chondral growth is up-regulated by mechanical signals.

J Dent Res 2002 81: 701-705. [Abstract] [Full Text] [Figures Only] [PDF]  

ERRATUM:

ERRATUM

J Dent Res 2002 81: 728. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

Odontoblasts Enhance the Maturation of Enamel Crystals by Secreting EMSP1 at the Enamel-Dentin Junction

M. Fukae, T. Tanabe, T. Nagano, H. Ando, Y. Yamakoshi, M. Yamada, J.P. Simmer, and S. Oida
Odontoblasts deposit EMSP1 via their cell processes into the deepest enamel layer, which facilitates the hardening of this layer and contributes significantly to the functional properties of the enamel-dentin junction.

J Dent Res 2002 81: 668-672. [Abstract] [Full Text] [Figures Only] [PDF]  

Expression of MMP-8 and MMP-13 mRNAs in Rat Periodontium during Tooth Eruption

M. Tsubota, Y. Sasano, I. Takahashi, M. Kagayama, and H. Shimauchi
This is the first report indicating expression of MMP-8 in periodontal ligament cells, cementoblasts, and cementocytes.

J Dent Res 2002 81: 673-678. [Abstract] [Full Text] [Figures Only] [PDF]  

Microarray Analysis of Gene Expression Changes in Aging in Mouse Submandibular Gland

K. Hiratsuka, Y. Kamino, T. Nagata, Y. Takahashi, S. Asai, K. Ishikawa, and Y. Abiko
This is the first investigation using DNA array technology for the identification of gene expression in salivary glands during aging.

J Dent Res 2002 81: 679-682. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Keratinocyte Growth Factor Receptor is Up-regulated in Cyclosporin A-induced Gingival Hyperplasia

S.J. Das, H.N. Newman, and I. Olsen
The keratinocyte growth factor-receptor pathway of mesenchymal-epithelial interaction could play in important part in the molecular pathogenesis of gingival hyperplasia.

J Dent Res 2002 81: 683-687. [Abstract] [Full Text] [Figures Only] [PDF]  

TGF-beta-3 Promotes Scarless Repair of Cleft Lip in Mouse Fetuses

K. Kohama, K. Nonaka, R. Hosokawa, L. Shum, and M. Ohishi
Microsurgical repair of cleft lip in the fetus that produced scarless fusion is mediated by TGF-ß3 regulation of mesenchymal cell proliferation and migration at the site of repair.

J Dent Res 2002 81: 688-694. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Mechanical Significance of the Trabecular Microstructure of the Human Mandibular Condyle

L.J. van Ruijven, E.B.W. Giesen, and T.M.G.J. van Eijden
The trabecular structure of the mandibular condyle is optimal to resist the compressive and tensile strains to which it is subjected.

J Dent Res 2002 81: 706-710. [Abstract] [Full Text] [Figures Only] [PDF]  

Diurnal Variation in the Response of the Mandible to Orthopedic Force

S. Yamada, S. Saeki, I. Takahashi, K. Igarashi, H. Shinoda, and H. Mitani
The orthopedic effects of mandibular retractive force vary, depending on the time of day the force is applied; such force may be more effective while animals are resting than while they are active.

J Dent Res 2002 81: 711-715. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Amplified Crevicular Leukocyte Activity in Aggressive Periodontal Disease

R. Buchmann, A. Hasilik, T.E. Van Dyke, and D.E. Lange
Effective treatment of periodontal disease can be measured with the use of biochemical markers of PMN activity, which is tightly regulated during periodontal inflammation, wound healing, and resolution, until homeostasis is achieved.

J Dent Res 2002 81: 716-721. [Abstract] [Full Text] [Figures Only] [PDF]  

Is Reduction of Pocket Probing Depth Correlated with the Baseline Value or is it "Mathematical Coupling"?

Y.-K. Tu, M.S. Gilthorpe, and G.S. Griffiths
To separate the artificial effect of mathematical coupling from the true underlying biological relationship, one must apply appropriate analytical strategies to re-evaluate previous evidence within the periodontal literature.

J Dent Res 2002 81: 722-726. [Abstract] [Full Text] [Figures Only] [PDF] [Data Supplement]  

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