D E P A R T M E N T S:

DISCOVERY!:

Can Systemic Diseases Co-induce (Not Just Exacerbate) Periodontitis? A Hypothetical "Two-hit" Model

L.M. Golub, J.B. Payne, R.A. Reinhardt, and G. Nieman
The authors conceptualize a "two-hit" model of chronic destructive periodontitis.

J Dent Res 2006 85: 102-105. [Full Text] [Figures Only] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Innate Immune Signaling and Porphyromonas gingivalis-accelerated Atherosclerosis

F.C. Gibson, III, H. Yumoto, Y. Takahashi, H.-H. Chou, and C.A. Genco
This review discusses the association between periodontal disease and the increased risk for heart disease and atherosclerosis, with particular emphasis on putative mechanisms linking P. gingivalis infection to the acceleration of atherosclerosis.

J Dent Res 2006 85: 106-121. [Abstract] [Full Text] [Figures Only] [PDF]  

The Role of Heparan Sulfate and Perlecan in Bone-regenerative Procedures

A.A. DeCarlo and J.M. Whitelock
The authors review the heparan-sulfate-decorated extracellular biomolecule named perlecan and the research relative to its potential as an adjunct in bone-regenerative procedures.

J Dent Res 2006 85: 122-132. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Biomaterials & Bioengineering:

Reduced Antigenicity of Type I Collagen and Proteoglycans in Sclerotic Dentin

P. Suppa, A. Ruggeri, Jr., F.R. Tay, C. Prati, M. Biasotto, M. Falconi, D.H. Pashley, and L. Breschi
The authors investigate the hypothesis that alterations in the antigenicity of type I collagen and proteoglycans occur in sclerotic dentin under caries lesions.

J Dent Res 2006 85: 133-137. [Abstract] [Full Text] [Figures Only] [PDF]  

Biological:

Cloning, Sequencing, and Expression of the Amelogenin Gene in Two Scincid Lizards

S. Delgado, M.-L. Couble, H. Magloire, and J.-Y. Sire
This is the first study to use in situ hybridization with a specific probe in a non-mammalian species to demonstrate that reptilian ameloblasts express amelogenin during amelogenesis.

J Dent Res 2006 85: 138-143. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Amelogenin-mediated Regulation of Osteoclastogenesis, and Periodontal Cell Proliferation and Migration

J. Hatakeyama, D. Philp, Y. Hatakeyama, N. Haruyama, L. Shum, M.A. Aragon, Z. Yuan, C.W. Gibson, T. Sreenath, H.K. Kleinman, and A.B. Kulkarni
The authors discuss the potential functions of M180 and leucine-rich amelogenin peptide in periodontal cells, especially in osteoclastogenesis and in the proliferation and migration of cementoblast/periodontal ligament cells.

J Dent Res 2006 85: 144-149. [Abstract] [Full Text] [Figures Only] [PDF]  

Differential uPA Expression by TGF-ß1 in Gingival Fibroblasts

P.C. Smith and J. Martínez
Stimulation of urokinase production by TGF-ß1 is involved in the responses of activated fibroblasts to tissue injury.

J Dent Res 2006 85: 150-155. [Abstract] [Full Text] [Figures Only] [PDF]  

Rosiglitazone Reduces the Evolution of Experimental Periodontitis in the Rat

R. Di Paola, E. Mazzon, D. Maiere, D. Zito, D. Britti, M. De Majo, T. Genovese, and S. Cuzzocrea
This study provides the first evidence that rosiglitazone causes a substantial reduction of ligature-induced periodontitis in rats.

J Dent Res 2006 85: 156-161. [Abstract] [Full Text] [Figures Only] [PDF]  

Articaine is More Effective than Lidocaine or Mepivacaine in Rat Sensory Nerve Conduction Block in vitro

I. Potocnik, M. Tomsic, J. Sketelj, and F.F. Bajrovic
The authors discuss the effectiveness of different anesthetic solutions in rat sensory nerve conduction block in vitro.

J Dent Res 2006 85: 162-166. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Origin of the Deciduous Upper Lateral Incisor and its Clinical Aspects

M. Hovorakova, H. Lesot, R. Peterkova, and M. Peterka
The authors investigated the origin of the deciduous upper lateral incisor in normal human embryos to elucidate the reasons for its developmental vulnerability.

J Dent Res 2006 85: 167-171. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Fluoride Varnish Efficacy in Preventing Early Childhood Caries

J.A. Weintraub, F. Ramos-Gomez, B. Jue, S. Shain, C.I. Hoover, J.D.B. Featherstone, and S.A. Gansky
Fluoride varnish added to caregiver counseling is efficacious in reducing early childhood caries incidence.

J Dent Res 2006 85: 172-176. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Mutans Streptococci Dose Response to Xylitol Chewing Gum

P. Milgrom, K.A. Ly, M.C. Roberts, M. Rothen, G. Mueller, and D.K. Yamaguchi
The aim of this study was to determine the relationship between dose and effects on mutans streptococci for adults chewing xylitol gum.

J Dent Res 2006 85: 177-181. [Abstract] [Full Text] [Figures Only] [PDF]  

The Transmission of Anaerobic Periodontopathic Organisms

Y. Lee, L.H. Straffon, K.B. Welch, and W.J. Loesche
The authors studied the prevalence of BANA-positive species in young children and their parents, seeking evidence of the potential transmission of periodontal pathogens between parents and their children.

J Dent Res 2006 85: 182-186. [Abstract] [Full Text] [PDF]  

Coordination of Tongue Pressure and Jaw Movement in Mastication

K. Hori, T. Ono, and T. Nokubi
The tongue plays a series of important roles in the total sequence of mastication of gummy jelly, by moving in coordination with jaw movement as well as controlling pressure against the hard palate.

J Dent Res 2006 85: 187-191. [Abstract] [Full Text] [Figures Only] [PDF]  

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