D E P A R T M E N T S:

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Dendritic Cells at the Oral Mucosal Interface

C.W. Cutler and R. Jotwani
The authors review the history of dendritic cells, their ontogeny, function, and phenotype, and the role of different dendritic cell subsets in the oral mucosa and its diseases.

J Dent Res 2006 85: 678-689. [Abstract] [Full Text] [Figures Only] [PDF]  

Preventive Intervention Possibilities in Radiotherapy- and Chemotherapy-induced Oral Mucositis: Results of Meta-analyses

M.A. Stokman, F.K.L. Spijkervet, H.M. Boezen, J.P. Schouten, J.L.N. Roodenburg, and E.G.E. de Vries
The authors report on meta-analyses that evaluated the effectiveness of interventions for the prevention of oral mucositis in cancer patients treated with head and neck radiotherapy and/or chemotherapy, with a focus on randomized clinical trials.

J Dent Res 2006 85: 690-700. [Abstract] [Full Text] [Figures Only] [PDF]  

DISCOVERY!:

Cervantes: Father of Don Quixote and Son of a Dentist

Antonio del Valle and Martín Romero
The authors have concluded that Cervantes’ father must have been a 16th Century dentist.

J Dent Res 2006 85: 701-704. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Clinical:

A Novel Mutation in ALK-1 Causes Hereditary Hemorrhagic Telangiectasia Type 2

Z.M. Yan, Z.P. Fan, J. Du, H. Hua, Y.Y. Xu, and S.L. Wang
This is the first detailed investigation of hereditary hemorrhagic telangiectasia in China published in an international journal.

J Dent Res 2006 85: 705-710. [Abstract] [Full Text] [Figures Only] [PDF]  

Stress and Inflammation as a Detrimental Combination for Peri-implant Bone Loss

S.M. Heckmann, J.J. Linke, F. Graef, Ch. Foitzik, M.G. Wichmann, and H.-P. Weber
The presence of stress heightens peri-implant bone loss significantly as inflammation increases.

J Dent Res 2006 85: 711-716. [Abstract] [Full Text] [Figures Only] [PDF]  

A Cost-effectiveness Analysis of Implant Overdentures

N.U. Zitzmann, C.P. Marinello, and P. Sendi
Over an assumed time horizon of 10 years, implant treatment becomes cost-effective, with implant-retained overdentures being the treatment of choice, if the patient is willing to pay at least 3,800 Swiss Francs for a Quality-adjusted Prosthesis Year gained.

J Dent Res 2006 85: 717-721. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Nano DCPA-Whisker Composites with High Strength and Ca and PO₄ Release

H.H.K. Xu, L. Sun, M.D. Weir, J.M. Antonucci, S. Takagi, L.C. Chow, and M. Peltz
The authors have combined, for the first time, nano-sized Ca- and PO₄-releasing fillers with reinforcing fillers in resins, yielding high-strength composites that may provide a unique combination of stress-bearing and caries-inhibiting capabilities.

J Dent Res 2006 85: 722-727. [Abstract] [Full Text] [Figures Only] [PDF]  

Contraction Stress in Dentin Adhesives Bonded to Dentin

M. Hashimoto, A.J. de Gee, M. Kaga, and A.J. Feilzer
A greater decline of stress after light-curing is seen for total-etch systems than for systems with self-etching primers.

J Dent Res 2006 85: 728-732. [Abstract] [Full Text] [Figures Only] [PDF]  

Biological:

Regulation of Cementoblast Function by P. gingivalis Lipopolysaccharide via TLR2

E. Nemoto, R.P. Darveau, B.L. Foster, G.R. Nogueira-Filho, and M.J. Somerman
The authors report for the first time that cementoblasts potentially participate in the recruitment of osteoclastic precursor cells by inducing chemokines/cytokines during periodontitis.

J Dent Res 2006 85: 733-738. [Abstract] [Full Text] [Figures Only] [PDF]  

Activation of Adenosine Receptor on Gingival Fibroblasts

T. Hashikawa, M. Takedachi, M. Terakura, S. Yamada, L.F. Thompson, Y. Shimabukuro, and S. Murakami
Ecto-adenosine deaminase metabolizes CD73-generated adenosine and regulates adenosine receptor activation.

J Dent Res 2006 85: 739-744. [Abstract] [Full Text] [Figures Only] [PDF]  

Elastolysis Induces Collagenolysis in a Gingival Lamina Propria Model

A. Cozlin, S. Barthelemy, R. Garnotel, F. Antonicelli, H. Kaplan, W. Hornebeck, and S. Lorimier
The authors propose that elastolysis, as occurring in periodontitis, potentiates collagenolysis, thus promoting disease progression.

J Dent Res 2006 85: 745-750. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

RANKL Increase in Compressed Periodontal Ligament Cells from Root Resorption

M. Yamaguchi, N. Aihara, T. Kojima, and K. Kasai
Compressed PDL cells obtained from severe external apical root resorption may produce a large amount of RANKL and up-regulate osteoclastogenesis.

J Dent Res 2006 85: 751-756. [Abstract] [Full Text] [Figures Only] [PDF]  

Clodronate Inhibits PGE₂ Production in Compressed Periodontal Ligament Cells

L. Liu, K. Igarashi, H. Kanzaki, M. Chiba, H. Shinoda, and H. Mitani
The inhibitory effects of clodronate on tooth movement and osteoclasts may be due, at least in part, to the inhibition of COX-2-dependent PGE₂ production and RANKL expression in PDL cells.

J Dent Res 2006 85: 757-760. [Abstract] [Full Text] [Figures Only] [PDF]  

Treponema denticola in Disseminating Endodontic Infections

F. Foschi, J. Izard, H. Sasaki, V. Sambri, C. Prati, R. Müller, and P. Stashenko
T. denticola has high pathogenicity, including dissemination to other organs, further substantiating its potential importance in oral and linked systemic conditions.

J Dent Res 2006 85: 761-765. [Abstract] [Full Text] [Figures Only] [PDF]  

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