D E P A R T M E N T S:

GUEST EDITORIAL:

A Global Theme — Poverty and Human Development

John S. Greenspan and Deborah Greenspan
The authors draw the attention of the dental research and professional communities to the severity and nature of oral and dental diseases as major global health crises of both acute and chronic types.

J Dent Res 2007 86: 917-918. [Full Text] [PDF]  

LETTER TO THE EDITOR:

LETTERS TO THE EDITOR

Anita Visser, Gerry M. Raghoebar, Henny J.A. Meijer, Arjan Vissink, Geert Stoker, Daniël Wismeijer, and Rien van Waas
J Dent Res 2007 86: 919-920. [Full Text] [PDF]  

LETTERS TO THE EDITOR

J. de Lange, A.V. van Gool, Geert Stoker, Daniël Wismeijer, and Rien van Waas
J Dent Res 2007 86: 920-921. [Full Text] [PDF]  

DISCOVERY!:

The Birth of the Most Important 18th Century Dental Text: Pierre Fauchard’s Le Chirurgien Dentist

Andrew I. Spielman
The author describes peer review in the 18th century.

J Dent Res 2007 86: 922-926. [Abstract] [Full Text] [Figures Only] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Angiogenesis Inhibitors and the Need for Anti-angiogenic Therapeutics

C.R. Dass, T.M.N. Tran, and P.F.M. Choong
This review looks at the common angiogenic inhibitors and their current status in clinical trials.

J Dent Res 2007 86: 927-936. [Abstract] [Full Text] [Figures Only] [PDF]  

VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification

J. Dai and A.B.M. Rabie
This review summarizes the family of VEGF-related molecules (including seven mammalian members), discusses current findings on endochondral ossification, and evaluates the therapeutic implications of recombinant VEGF-A protein therapy and VEGF-A gene therapy.

J Dent Res 2007 86: 937-950. [Abstract] [Full Text] [Figures Only] [PDF]  

RAPID COMMUNICATION:

A Novel Role for Twist-1 in Pulp Homeostasis

K.M. Galler, A. Yasue, A.C. Cavender, P. Bialek, G. Karsenty, and R.N. D’Souza
Twist-1 plays a key role in restraining odontoblast differentiation, thus maintaining homeostasis in dental pulp.

J Dent Res 2007 86: 951-955. [Abstract] [Full Text] [Figures Only] [PDF] Appendix  

R E S E A R C H  R E P O R T S:

Biological:

The Cranial Base in Craniofacial Development: a Gene Therapy Study

S. Kyrkanides, P. Kambylafkas, J.H. Miller, R.H. Tallents, and J.E. Puzas
Timely restitution of a genetic deficiency or, alternatively, the restoration of PTHrP or cyclo-oxygenase activity by the administration of PTH and/or NSAIDs or COX-2 selective inhibitors to affected individuals may prove beneficial in the management of midface retrusion.

J Dent Res 2007 86: 956-961. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Splicing Determines the Glycosylation State of Ameloblastin

K. Kobayashi, Y. Yamakoshi, J.C.-C. Hu, K. Gomi, T. Arai, M. Fukae, P.H. Krebsbach, and J.P. Simmer
This is the first demonstration that ameloblastin is glycosylated in its N-terminal region.

J Dent Res 2007 86: 962-967. [Abstract] [Full Text] [Figures Only] [PDF]  

Targeting and Immobilization of Bioactive Peptides on Dentin Matrix

J.S. Song, A. Wlodarska, H.J. Ko, and W.J. Grzesik
Transglutaminase-catalyzed covalent binding of bioactive peptides targeted to mineralized collagenous dentin matrix via the poly-glutamate domain can be readily achieved, and this method may be of clinical use in periodontal regeneration.

J Dent Res 2007 86: 968-973. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

PGE₂ Activates Cementoclastogenesis by Cementoblasts via EP4

H. Oka, M. Miyauchi, K. Sakamoto, S. Moriwaki, S. Niida, K. Noguchi, M.J. Somerman, and T. Takata
PGE₂ promotes cementoblast-mediated cementoclastogenesis by regulating the expression of RANKL and OPG via the EP4 pathway.

J Dent Res 2007 86: 974-979. [Abstract] [Full Text] [Figures Only] [PDF]  

Enamel Matrix Derivative Promotes Human Periodontal Ligament Cell Differentiation and Osteoprotegerin Production in vitro

S. Lossdörfer, M. Sun, W. Götz, M. Dard, and A. Jäger
Enamel matrix derivative promotes periodontal ligament cell differentiation and osteoprotegerin production, potentially resulting in a microenvironment supporting periodontal repair.

J Dent Res 2007 86: 980-985. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

Defining Subphenotypes for Oral Clefts Based on Dental Development

A. Letra, R. Menezes, J.M. Granjeiro, and A.R. Vieira
This is the first study to use dental anomalies to subphenotype the three major categories of oral clefts (cleft lip only, cleft lip with cleft palate, and cleft palate only).

J Dent Res 2007 86: 986-991. [Abstract] [Full Text] [PDF] [Appendix]  

Social Gradients in Oral and General Health

W. Sabbah, G. Tsakos, T. Chandola, A. Sheiham, and R.G. Watt
There are commonalities of the social determinants of both oral and general health.

J Dent Res 2007 86: 992-996. [Abstract] [Full Text] [Figures Only] [PDF]  

Association among Bad Breath, Body Mass Index, and Alcohol Intake

M. Rosenberg, T. Knaan, and D. Cohen
This is the first study showing significant associations between alcohol consumption and bad breath.

J Dent Res 2007 86: 997-1000. [Abstract] [Full Text] [PDF]  

Biomaterials & Bioengineering:

Effects of Dentin Characteristics on Interfacial Nanoleakage

Y. Yuan, Y. Shimada, S. Ichinose, A. Sadr, and J. Tagami
Characteristics of substrate dentin and type of adhesive used for bonding affect the formation of nanoleakage.

J Dent Res 2007 86: 1001-1006. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

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