D E P A R T M E N T S:

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Osteonecrosis of the Jaws and Bisphosphonate Therapy

S.L. Ruggiero and S.J. Drew
Osteonecrosis of the jaw is a new and emerging complication of bisphosphonate therapy that is associated with significant morbidity, and often requires symptomatic management for palliation in certain patients, causing clinicians to re-evaluate the indications for and duration of such therapy for osteopenia/osteoporosis and cancer patients.

J Dent Res 2007 86: 1013-1021. [Abstract] [Full Text] [Figures Only] [PDF]  

Mechanism of Action, Pharmacokinetic and Pharmacodynamic Profile, and Clinical Applications of Nitrogen-containing Bisphosphonates

D.B. Kimmel
Nitrogen-containing bisphosphonates are by far the most efficacious treatment available for reducing the risk of fracture in osteoporotic patients and skeletal-related events in breast, lung, and prostate cancer patients and multiple myeloma patients.

J Dent Res 2007 86: 1022-1033. [Abstract] [Full Text] [Figures Only] [PDF]  

ERRATUM:

ERRATUM

J Dent Res 2007 86: 1126. [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Biomaterials & Bioengineering:

Bonding BisGMA to Dentin—a Proof of Concept for Hydrophobic Dentin Bonding

F.R. Tay, D.H. Pashley, R.R. Kapur, M.R.O. Carrilho, Y.B. Hur, L.V. Garrett, and K.C.Y. Tay
Experimental BisGMA adhesives provide the proof of concept that relatively hydrophobic resins may be coupled to acid-etched dentin by increasing its hydrophobic characteristics via ethanol replacement.

J Dent Res 2007 86: 1034-1039. [Abstract] [Full Text] [Figures Only] [PDF]  

Effects of Hydrogen Peroxide on Human Dentin Structure

T. Jiang, X. Ma, Y. Wang, Z. Zhu, H. Tong, and J. Hu
H₂O₂ may cause the destruction of dentin by a mechanism of protein oxidation, a discovery that offers new insights into changes in the mineral components of dentin.

J Dent Res 2007 86: 1040-1045. [Abstract] [Full Text] [Figures Only] [PDF]  

Sliding Contact Fatigue Damage in Layered Ceramic Structures

J.-W. Kim, J.-H. Kim, V.P. Thompson, and Y. Zhang
Sliding action must be considered in any laboratory simulation of the clinical environment intended to establish the longevity of all-ceramic crowns.

J Dent Res 2007 86: 1046-1050. [Abstract] [Full Text] [Figures Only] [PDF]  

Rat Nerve Regeneration with the Use of a Polymeric Membrane Loaded with NGF

M. Savignat, L. De-Doncker, C. Vodouhe, J.M. Garza, P. Lavalle, and P. Libersa
The application of nerve growth factor through a polymeric membrane could have important therapeutic implications for nerve regeneration after a crush injury.

J Dent Res 2007 86: 1051-1056. [Abstract] [Full Text] [Figures Only] [PDF]  

Synthesizing Dental Radiographs for Human Identification

S. Tohnak, A.J.H. Mehnert, M. Mahoney, and S. Crozier
This research demonstrates that radiograph-like images with minimal geometric distortion, reduced blurring, and reduced superimposition of oral structures, compared with conventional radiographs, can be synthesized from x-ray CT data, and that such images can serve as the basis for the development of a computerized image analysis system to assist the forensic dentist with the task of identifying human remains.

J Dent Res 2007 86: 1057-1062. [Abstract] [Full Text] [Figures Only] [PDF]  

Biological:

Modulation of Epithelial Cell Fate of the Root in vitro

M. Tummers, T. Yamashiro, and I. Thesleff
The fate of the epithelium is regulated by external cues influenced by culture conditions, and the mouse molar has the intrinsic capacity to grow continuously.

J Dent Res 2007 86: 1063-1067. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Craniofacial Morphology in Myostatin-deficient Mice

L. Vecchione, C. Byron, G.M. Cooper, T. Barbano, M.W. Hamrick, J.J. Sciote, and M.P. Mooney
Masticatory muscle function plays an important role in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.

J Dent Res 2007 86: 1068-1072. [Abstract] [Full Text] [Figures Only] [PDF]  

Inhibition of Trigeminal Respiratory Activity by Suckling

H. Koizumi, K. Nomura, K. Ishihama, T. Yamanishi, A. Enomoto, and M. Kogo
The brainstem preparation contains an inhibitory circuit for respiratory activity in the trigeminal motor system by the rhythm-generating network for suckling.

J Dent Res 2007 86: 1073-1077. [Abstract] [Full Text] [Figures Only] [PDF]  

Guiding Periodontal Pocket Recolonization: a Proof of Concept

W. Teughels, M.G. Newman, W. Coucke, A.D. Haffajee, H.C. Van Der Mei, S. Kinder Haake, E. Schepers, J.-J. Cassiman, J. Van Eldere, D. van Steenberghe, and M. Quirynen
This is the first study to test the concept of bacterial replacement therapy in the treatment of plaque-related periodontal disease.

J Dent Res 2007 86: 1078-1082. [Abstract] [Full Text] [Figures Only] [PDF]  

Histamine Amplifies Immune Response of Gingival Fibroblasts

T. Minami, T. Kuroishi, A. Ozawa, H. Shimauchi, Y. Endo, and S. Sugawara
Histamine induces IL-8 production from gingival fibroblasts through H1R and synergistically augments the inflammatory stimuli by amplification of the MAPK and NF-B through H1R-linked phospholipase C.

J Dent Res 2007 86: 1083-1088. [Abstract] [Full Text] [Figures Only] [PDF]  

The Role of Tumor Necrosis Factor Receptor Type 1 in Orthodontic Tooth Movement

I. Andrade, Jr., T.A. Silva, G.A.B. Silva, A.L. Teixeira, and M.M. Teixeira
The TNFR-1 plays a significant role in orthodontic tooth movement that might be associated with changes in CCL5 levels.

J Dent Res 2007 86: 1089-1094. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

The Effect of LRAP on Enamel Organ Epithelial Cell Differentiation

T.Q. Le, Y. Zhang, W. Li, and P.K. DenBesten
This study provides new insights into the effect of rH58 on the synthesis of proteins that control the process of dental epithelial cell differentiation, regulating tooth enamel formation.

J Dent Res 2007 86: 1095-1099. [Abstract] [Full Text] [Figures Only] [PDF]  

Stimulation of Cells Derived from Nifedipine-induced Gingival Overgrowth with Porphyromonas gingivalis, Lipopolysaccharide, and Interleukin-1ß

H.-K. Lu, H.-P. Chou, C.-L. Li, M.-Y. Wang, and L.-F. Wang
IL-1ß, but not Pg-LPS or nifedipine, is the major mediator responsible for the higher IL-6 androgen receptor expression of nifedipine-induced gingival overgrowth cells.

J Dent Res 2007 86: 1100-1104. [Abstract] [Full Text] [Figures Only] [PDF]  

Oral Health Impact of Periodontal Diseases in Adolescents

R. López and V. Baelum
The authors’ results demonstrate the existence of tacit self-perceived impact on the oral-health-related quality of life in a group of adolescents, which seems to be reflected in the clinical observations made by dental professionals.

J Dent Res 2007 86: 1105-1109. [Abstract] [Full Text] [Figures Only] [PDF]  

Longitudinal Study of Bone Density and Periodontal Disease in Men

K.R. Phipps, B.K.S. Chan, T.E. Madden, N.C. Geurs, M.S. Reddy, C.E. Lewis, and E.S. Orwoll
This is the first study to evaluate the relationship among clinical measures of periodontal status, periodontal disease progression, and skeletal bone mineral density in a large, well-characterized cohort of older men.

J Dent Res 2007 86: 1110-1114. [Abstract] [Full Text] [PDF]  

Longitudinal Relationship between Root Caries and Serum Albumin

A. Yoshihara, N. Takano, T. Hirotomi, H. Ogawa, N. Hanada, and H. Miyazaki
This is the first longitudinal study to clarify the relationship between root caries and serum albumin levels in the elderly.

J Dent Res 2007 86: 1115-1119. [Abstract] [Full Text] [Figures Only] [PDF]  

Influence of Psychological Factors on Risk of Temporomandibular Disorders

G.D. Slade, L. Diatchenko, K. Bhalang, A. Sigurdsson, R.B. Fillingim, I. Belfer, M.B. Max, D. Goldman, and W. Maixner
Psychological characteristics linked to pain sensitivity influence TMD risk independently of the effects of the COMT haplotype on TMD risk.

J Dent Res 2007 86: 1120-1125. [Abstract] [Full Text] [Figures Only] [PDF]  

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