D E P A R T M E N T S:

DISCOVERY!:

Creating a Model for Graduate Education in Hospital Dentistry: a Memoir from Montefiore Medical Center and the Albert Einstein College of Medicine

Norman Trieger
The author traces the history of graduate education in hospital dentistry at two institutions.

J Dent Res 2007 86: 797-799. [Full Text] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

p38 Pathway Kinases as Anti-inflammatory Drug Targets

J.F. Schindler, J.B. Monahan, and W.G. Smith
The role of MAPK in inflammation makes them attractive targets for new therapies, and efforts are continuing to identify newer, more selective inhibitors for inflammatory disease.

J Dent Res 2007 86: 800-811. [Abstract] [Full Text] [Figures Only] [PDF]  

p38 MAPK Signaling in Oral-related Diseases

C.S. Patil and K.L. Kirkwood
The authors present evidence for the significance of p38 MAPK signaling in diverse dental diseases, including chronic pain, desquamative disorders, and periodontal diseases.

J Dent Res 2007 86: 812-825. [Abstract] [Full Text] [Figures Only] [PDF]  

R E S E A R C H  R E P O R T S:

Clinical:

Autoimmunity to deltaNp63alpha in Chronic Ulcerative Stomatitis

L.W. Solomon, M.E. Neiders, M.G. Zwick, K.L. Kirkwood, and V. Kumar
This is the first study to examine the cross-reactivity of chronic ulcerative stomatitis patient antibodies with p53 family isoforms.

J Dent Res 2007 86: 826-831. [Abstract] [Full Text] [Figures Only] [PDF]  

Cholinoreceptor Autoantibodies in Sjögren Syndrome

S. Reina, B. Orman, J.M. Anaya, L. Sterin-Borda, and E. Borda
The authors discuss the importance of autoantibodies to cholinoreceptors in the generation of chronic inflammation of target tissues in Sjögren syndrome.

J Dent Res 2007 86: 832-836. [Abstract] [Full Text] [Figures Only] [PDF]  

Identification of a Sleep Bruxism Subgroup with a Higher Risk of Pain

P.H. Rompré, D. Daigle-Landry, F. Guitard, J.Y. Montplaisir, and G.J. Lavigne
Sleep bruxers with low frequencies of orofacial activities are more at risk of reporting pain.

J Dent Res 2007 86: 837-842. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Jaw Clenching: Muscle and Joint Forces, Optimization Strategies

H.J. Schindler, S. Rues, J.C. Türp, K. Schweizerhof, and J. Lenz
Clenching experiments and consecutive biomechanical simulations based on anatomical data, EMG, and force measurement of one sample were performed to calculate muscle and joint forces, and to identify motor control strategies.

J Dent Res 2007 86: 843-847. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Hop Bract Polyphenols Reduced Three-day Dental Plaque Regrowth

K. Shinada, M. Tagashira, H. Watanabe, P. Sopapornamorn, A. Kanayama, T. Kanda, M. Ikeda, and Y. Kawaguchi
Hop bract polyphenols, delivered in a mouthrinse, successfully reduced dental plaque regrowth in humans.

J Dent Res 2007 86: 848-851. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Depression as a Risk Factor for Denture Dissatisfaction

M.T. John, W. Micheelis, and J.G. Steele
The likely causal association in older adults has major implications for the evaluation of treatment effects and the demand for prosthodontic therapy.

J Dent Res 2007 86: 852-856. [Abstract] [Full Text] [PDF]  

Dentin in Severe Fluorosis: a Quantitative Histochemical Study

F. Rojas-Sánchez, M. Alaminos, A. Campos, H. Rivera, and M.C. Sánchez-Quevedo
The hypermineralization response of dentin suggests that the mechanism of the response should be taken into account in dental caries and other dental disorders associated with severe fluorosis.

J Dent Res 2007 86: 857-861. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Molecular Analysis of Healing at a Bone-Implant Interface

C. Colnot, D.M. Romero, S. Huang, J. Rahman, J.A. Currey, A. Nanci, J.B. Brunski, and J.A. Helms
The authors describe a new model for use as a test bed for the study of cellular and molecular responses to biomaterials and biomechanical conditions.

J Dent Res 2007 86: 862-867. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Pre-overloading to Extend Fatigue Life of Cast Clasps

A. Mahmoud
Pre-overloaded specimens demonstrated fatigue lives significantly longer than those tested in the as-cast condition, consistent with the maximum tensile stress values revealed by finite element analysis.

J Dent Res 2007 86: 868-872. [Abstract] [Full Text] [Figures Only] [PDF]  

Biological:

Inhibition of SFRP1 Reduces Severity of Periodontitis

C.H. Li and S. Amar
Secreted frizzled-related protein 1 may be involved in the development of periodontitis, since inhibiting it resulted in reduced periodontal breakdown.

J Dent Res 2007 86: 873-877. [Abstract] [Full Text] [Figures Only] [PDF]  

Hemoglobin and LPS Act in Synergy to Amplify the Inflammatory Response

C. Bodet, F. Chandad, and D. Grenier
The authors present clear evidence that hemoglobin contributes to enhancing the levels of pro-inflammatory mediators in periodontal sites, by acting in synergy with LPS from periodontopathogens, a phenomenon that may contribute significantly to the progression and severity of periodontitis.

J Dent Res 2007 86: 878-882. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

VIP Inhibits P. gingivalis LPS-induced IL-18 and IL-18BPa in Monocytes

N. Foster, K. Andreadou, L. Jamieson, P.M. Preshaw, and J.J. Taylor
IL-18 and IL-18BPa secretion by monocytes is part of the immune response to Porphyromonas gingivalis, and vasoactive intestinal peptide can inhibit this process.

J Dent Res 2007 86: 883-887. [Abstract] [Full Text] [Figures Only] [PDF]  

Apoptosis in Gingival Overgrowth Tissues

A. Kantarci, P. Augustin, E. Firatli, M.C. Sheff, H. Hasturk, D.T. Graves, and P.C. Trackman
This is the first evidence for FOXO1 regulation in gingival tissues.

J Dent Res 2007 86: 888-892. [Abstract] [Full Text] [Figures Only] [PDF]  

Inorganic Polyphosphate: a Possible Stimulant of Bone Formation

Y. Hacchou, T. Uematsu, O. Ueda, Y. Usui, S. Uematsu, M. Takahashi, T. Uchihashi, Y. Kawazoe, T. Shiba, S. Kurihara, M. Yamaoka, and K. Furusawa
Inorganic polyphosphates [poly(P)] play a role in osteoblastic differentiation, activation, and bone mineralization; thus, local poly(P) delivery may have a therapeutic benefit in periodontal disease.

J Dent Res 2007 86: 893-897. [Abstract] [Full Text] [Figures Only] [PDF]  

Eugenol Inhibits K⁺ Currents in Trigeminal Ganglion Neurons

H.Y. Li, C.-K. Park, S.J. Jung, S.-Y. Choi, S.J. Lee, K. Park, J.S. Kim, and S.B. Oh
The inhibition of voltage-gated K⁺ currents is likely to contribute to the irritable action of eugenol.

J Dent Res 2007 86: 898-902. [Abstract] [Full Text] [Figures Only] [PDF]  

Hypoxia Induces Expression and Activation of AMPK in Rat Dental Pulp Cells

Y. Fukuyama, K. Ohta, R. Okoshi, M. Suehara, H. Kizaki, and K. Nakagawa
The authors’ findings will help identify novel targets for the development of vital pulp therapy.

J Dent Res 2007 86: 903-907. [Abstract] [Full Text] [Figures Only] [PDF]  

Peritubular Dentin Lacks Piezoelectricity

S. Habelitz, B.J. Rodriguez, S.J. Marshall, G.W. Marshall, S.V. Kalinin, and A. Gruverman
This study supports the hypothesis that peritubular dentin is a non-collagenous tissue and is thus an exception among mineralized tissues that derive from the mesenchyme.

J Dent Res 2007 86: 908-911. [Abstract] [Full Text] [Figures Only] [PDF]  

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