D E P A R T M E N T S:

GUEST EDITORIAL:

Has Dental Amalgam Been Torpedoed and Sunk?

Derek W. Jones
The author discusses new Norwegian regulations governing mercury that will adversely affect the use of dental amalgam not only there, but also in other countries around the world.

J Dent Res 2008 87: 101-102. [Full Text] [PDF]  

DISCOVERY!:

The Nature and Formation of Teeth According to Spanish Authors from the 16th to the 18th Centuries

M. Romero-Maroto and J.M. Sáez-Gómez
The authors present the state of scientific knowledge that prevailed in the Modern Age concerning the nature and origin of teeth, especially the acquisition of this knowledge by Spanish authors and their contributions to the subject.

J Dent Res 2008 87: 103-106. [Full Text] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis

Z.S. AI-Aql, A.S. Alagl, D.T. Graves, L.C. Gerstenfeld, and T.A. Einhorn
The cellular and molecular mechanisms that regulate fracture repair are contrasted with bone regeneration that occurs during distraction osteogenesis.

J Dent Res 2008 87: 107-118. [Abstract] [Full Text] [Figures Only] [PDF]  

Unraveling Human Cleft Lip and Palate Research

A.R. Vieira
This review highlights the most recent advances in the understanding of cleft lip and palate occurrence.

J Dent Res 2008 87: 119-125. [Abstract] [Full Text] [Figures Only] [PDF]  

ERRATUM:

ERRATUM

J Dent Res 2008 87: 191. [Full Text] [PDF]  

R E S E A R C H  R E P O R T S:

Biological:

Wnt/β-catenin Inhibits Dental Pulp Stem Cell Differentiation

E.L. Scheller, J. Chang, and C.Y. Wang
This is the first report that canonical Wnt signaling can inhibit the odontoblast-like differentiation of dental pulp stem cells.

J Dent Res 2008 87: 126-130. [Abstract] [Full Text] [Figures Only] [PDF]  

HUGO (FNDC3A): a New Gene Overexpressed in Human Odontoblasts

F. Carrouel, M.-L. Couble, C. Vanbelle, M.-J. Staquet, H. Magloire, and F. Bleicher
This is the first characterization of a new gene, HUGO, and its associated deduced protein sequence.

J Dent Res 2008 87: 131-136. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Modulation of Ca_V2.3 Calcium Channel Currents by Eugenol

G. Chung, J.N. Rhee, S.J. Jung, J.S. Kim, and S.B. Oh
Inhibition of Ca_V2.3 channels by eugenol might contribute to its analgesic effect.

J Dent Res 2008 87: 137-141. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Estrogen Modulates Cytokine Expression in Human Periodontal Ligament Cells

L. Shu, S.-M. Guan, S.-M. Fu, T. Guo, M. Cao, and Y. Ding
Estrogen may play a significant role in modulating periodontal tissue responses to lipopolysaccharide, and may exert its bone-sparing effects on periodontal tissues via altering the expression of inflammatory cytokines in human periodontal ligament cells.

J Dent Res 2008 87: 142-147. [Abstract] [Full Text] [Figures Only] [PDF]  

Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial

Q. Luan, T. Desta, L. Chehab, V.J. Sanders, J. Plattner, and D.T. Graves
The authors describe a boron-containing compound that significantly reduces the formation of an inflammatory infiltrate and reduces bone loss, measured histologically and by micro-CT.

J Dent Res 2008 87: 148-152. [Abstract] [Full Text] [Figures Only] [PDF]  

Mandibular Appliance Modulates Condylar Growth through Integrins

M. Rubia Marques, D. Hajjar, K. Gomes Franchini, A. Sigari Moriscot, and M. Fagundes Santos
Force itself modulates the growth of the rat condylar cartilage, and RGD-binding integrins participate in mechanotransduction.

J Dent Res 2008 87: 153-158. [Abstract] [Full Text] [Figures Only] [PDF]  

Insulin-like Growth Factor I Regulates Apoptosis in Condylar Cartilage

T. Yokota, H. Shimokawa, S. Shibata, K. Itoh, Y. Baba, K. Ohya, K. Ohyama, and S. Suzuki
Cells in the undifferentiated mesenchymal cell layer of the mandibular condyle require endogenous insulin-like growth factor I for survival.

J Dent Res 2008 87: 159-163. [Abstract] [Full Text] [Figures Only] [PDF]  

Clinical:

An Uncommon Cleft Subtype of Unilateral Cleft Lip and Palate

T. Yamanishi, C. Kobayashi, I. Tsujimoto, H. Koizumi, S. Miya, Y. Yokota, R. Okamoto, S. Iida, T. Aikawa, H. Kohara, J. Nishio, and M. Kogo
This is the first study to analyze the palatal morphology of an uncommon bilateral cleft subtype in persons with unilateral cleft lip and palate.

J Dent Res 2008 87: 164-168. [Abstract] [Full Text] [Figures Only] [PDF]  

The Effectiveness of Sealants in Managing Caries Lesions

S.O. Griffin, E. Oong, W. Kohn, B. Vidakovic, B.F. Gooch, CDC Dental Sealant Systematic Review Work Group, J. Bader, J. Clarkson, M.R. Fontana, D.M. Meyer, R.G. Rozier, J.A. Weintraub, and D.T. Zero
Sealing non-cavitated caries in permanent teeth is effective in reducing caries progression.

J Dent Res 2008 87: 169-174. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Periodontal-Masseteric Reflexes Decrease with Tooth Pre-load

P.F. Sowman and K.S. Türker
The authors used a new method in concluding that periodontal mechanoreceptors are able to contribute to the ongoing control of only small bite-forces.

J Dent Res 2008 87: 175-179. [Abstract] [Full Text] [Figures Only] [PDF]  

Biomaterials & Bioengineering:

Scaffold and Growth Factor Selection in Temporomandibular Joint Disc Engineering

K.D. Allen and K.A. Athanasiou
This is the first TMJ disc tissue-engineering study to report construct tensile properties, maintain testable tensile integrity, and demonstrate statistical increases.

J Dent Res 2008 87: 180-185. [Abstract] [Full Text] [Figures Only] [PDF]  

Surface Roughness Analysis of Fiber Post Conditioning Processes

C. Mazzitelli, M. Ferrari, M. Toledano, E. Osorio, F. Monticelli, and R. Osorio
Surface-conditioning procedures that selectively react with the epoxy-resin matrix of the fiber post enhance roughness and improve the surface area available for adhesion by creating micro-retentive spaces without affecting the post’s inner structure.

J Dent Res 2008 87: 186-190. [Abstract] [Full Text] [Figures Only] [PDF]  

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