D E P A R T M E N T S:

EDITORIAL:

Research Integrity and Scientific Misconduct

Anthony J. (Tony) Smith
J Dent Res 2008 87: 197. [Full Text] [PDF]  

LETTERS TO THE EDITOR:

Pre-odontoblasts, Odontoblasts, or "Odontocytes"

Markku Larmas, Dedong Ma, Cielo Barragan-Adjemian, Yixia Xie, Yongbo Lu, Lynda F. Bonewald, and Jian Q. Feng
J Dent Res 2008 87: 198-199. [Full Text] [Figures Only] [PDF]  

DISCOVERY!:

The Endangered Clinical Teacher Scholar: Will this Eliminate Discovery from the Dental School Environment?

M. Oakley and A.R. Vieira
Without a definitive plan, the clinical scholar will be an endangered species, and research innovations and professional discovery will fall short in addressing the needs of the public’s oral and systemic health.

J Dent Res 2008 87: 200-202. [Abstract] [Full Text] [PDF]  

CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE:

Beyond Good and Evil in the Oral Cavity: Insights into Host-Microbe Relationships Derived from Transcriptional Profiling of Gingival Cells

M. Handfield, H.V. Baker, and R.J. Lamont
This is the first report that systematically investigates the cellular responses of a cell line to challenge by four different micro-organisms, providing a molecular basis for the complex and dynamic interactions between the oral microflora and its host, which may lead, ultimately, to the development of novel, rational, and practical therapeutic, prophylactic, and diagnostic applications.

J Dent Res 2008 87: 203-223. [Abstract] [Full Text] [Figures Only] [PDF] Appendix  

R E S E A R C H  R E P O R T S:

Biomaterials & Bioengineering:

Effects of Fluoride Dentifrices on Enamel Lesion Formation

S. Toda and J.D. Featherstone
This is the first comparison of three fluoride-containing compounds in a pH cycling model to test their effects on de/remineralization as a function of the free fluoride ion concentration.

J Dent Res 2008 87: 224-227. [Abstract] [Full Text] [Figures Only] [PDF]  

Active Management of Incipient Caries and Choice of Materials

C. Trairatvorakul, S. Kladkaew, and S. Songsiripradabboon
This is the first study to compare, in one setting, four materials commonly used in stabilizing or reversing incipient caries lesions.

J Dent Res 2008 87: 228-232. [Abstract] [Full Text] [Figures Only] [PDF]  

Micromechanical Property Recovery of Human Carious Dentin Achieved with Colloidal Nano-β-tricalcium Phosphate

Y. Shibata, L.H. He, Y. Kataoka, T. Miyazaki, and M.V. Swain
Compared with colloidal hydroxyapatite, colloidal β-tricalcium phosphate was shown to achieve better recovery of micromechanical properties in carious dentin.

J Dent Res 2008 87: 233-237. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Biological:

Epithelial Fibroblast Growth Factor Receptor 1 Regulates Enamel Formation

K. Takamori, R. Hosokawa, X. Xu, X. Deng, P. Bringas, Jr., and Y. Chai
There is a cell-intrinsic requirement for FGF signaling in the dental epithelium during enamel formation.

J Dent Res 2008 87: 238-243. [Abstract] [Full Text] [Figures Only] [PDF]  

Wnt/β-catenin Signaling Regulates Cranial Base Development and Growth

M. Nagayama, M. Iwamoto, A. Hargett, N. Kamiya, Y. Tamamura, B. Young, T. Morrison, H. Takeuchi, M. Pacifici, M. Enomoto-Iwamoto, and E. Koyama
Wnt-β-catenin signaling is essential for cranial base development and synchondrosis growth plate function.

J Dent Res 2008 87: 244-249. [Abstract] [Full Text] [Figures Only] [PDF]  

Inhibition of Human Dental Pulp Stem Cell Differentiation by Notch Signaling

C. Zhang, J. Chang, W. Sonoyama, S. Shi, and C.-Y. Wang
This is the first demonstration that the activation of Notch signaling by Jagged-1 can inhibit the odontoblastic differentiation of DPSCs in vitro and in vivo.

J Dent Res 2008 87: 250-255. [Abstract] [Full Text] [Figures Only] [PDF]  

Different Roles of Odontoblasts and Fibroblasts in Immunity

M.-J. Staquet, S.H. Durand, E. Colomb, A. Roméas, C. Vincent, F. Bleicher, S. Lebecque, and J.-C. Farges
Odontoblasts and pulp fibroblasts differ in their innate immune responses to oral micro-organisms that invade the pulp tissue.

J Dent Res 2008 87: 256-261. [Abstract] [Full Text] [Figures Only] [PDF]  

Trigeminal Nociceptors Express Prostaglandin Receptors

A.M. Patwardhan, J. Vela, J. Farugia, K. Vela, and K.M. Hargreaves
Prostaglandin receptors EP2 and EP3 are expressed by trigeminal nociceptors, and their activation modulates TRPV₁.

J Dent Res 2008 87: 262-266. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Effects of IL-17 on Human Gingival Fibroblasts

R. Mahanonda, P. Jitprasertwong, N. Sa-Ard-Iam, P. Rerkyen, O. Charatkulangkun, P. Jansisyanont, K. Nisapakultorn, K. Yongvanichit, and S. Pichyangkul
IL-17, especially when combined with IFN-, could play an important role in immune modulation through stimulation of human gingival fibroblasts in periodontal disease.

J Dent Res 2008 87: 267-272. [Abstract] [Full Text] [Figures Only] [PDF] [Appendix]  

Clinical:

Tumor Necrosis Factor--converting Enzyme (TACE) Levels in Periodontal Diseases

N. Bostanci, G. Emingil, B. Afacan, B. Han, T. Ilgenli, G. Atilla, F.J. Hughes, and G.N. Belibasakis
This is the first study to investigate the involvement of TACE in periodontal diseases, demonstrating that total TACE amounts in GCF are elevated in chronic and aggressive periodontitis, compared with health or gingivitis.

J Dent Res 2008 87: 273-277. [Abstract] [Full Text] [Figures Only] [PDF]  

Diversity of Veillonella spp. from Sound and Carious Sites in Children

N. Arif, E.C. Sheehy, T. Do, and D. Beighton
The Veillonella from caries-free sites were more diverse than those from caries lesions and may be related to the acidic environment of caries lesions.

J Dent Res 2008 87: 278-282. [Abstract] [Full Text] [Figures Only] [PDF]  

Age and Third Molar Extraction as Risk Factors for Temporomandibular Disorder

G.J. Huang, M.T. Drangsholt, T.C. Rue, D.C. Cruikshank, and K.A. Hobson
This study investigated third molar removal as a risk factor for temporomandibular disorder in all age groups.

J Dent Res 2008 87: 283-287. [Abstract] [Full Text] [Figures Only] [PDF]  

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